HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Aminoethyl)-1-methylpyrrolidine → 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-{3-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-ureido}-isothiazole-4-carboxylic Acid Amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Aminoethyl)-1-methylpyrrolidine | HCID 98388 | — |
| Reactant | (4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester | HCID 11384589 | — |
| Product | 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-{3-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-ureido}-isothiazole-4-carboxylic Acid Amide | HCID 10479075 | — |
Reaction Steps
The title compound was prepared from [4-carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 2-(1-methyl-pyrrolidin-2-yl)-ethylamine by the procedure analogous to Example 1. MS (APCl, m/z): 454 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548526B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-9ecafe8f6dee4199bdc5c59cf2c3ac25 |
| Source note | uspto-grants-2003_04 |