HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 3-[1-(2-Methoxyphenyl)-cyclopropyl]-2-oxo-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | (2-Methoxyphenyl)acetonitrile | HCID 81496 | — |
| Reactant | 3-(1-Phenyl-cyclobutyl)-2-oxopropionic acid | HCID 18551262 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | 3-[1-(2-Methoxyphenyl)-cyclopropyl]-2-oxo-propionic acid | HCID 18551214 | — |
Reaction Steps
Corresponding to J. Org. Chem. 40 (1975) 3497, 16.7 g of 2-methoxyphenylacetonitrile, 158 ml of lithium triisopropyl-amide (2 mol solution) and 46.7 ml of 1,2-dichloroethane in 96 ml of tetrahydrofuran and 58.6 ml of hexamethylphosphoric acid triamide are reacted with one another. 5.6 g of 1-(2-methoxy-phenyl)-cyclopropyl-carbonitrile, boiling point 104-115° C./0.1 mbar, which was also reacted as described for 3-(1-phenyl-cyclobutyl)-2-oxo-propionic acid, is obtained. 3-[1-(2-Methoxyphenyl)-cyclopropyl]-2-oxo-propionic acid is thus obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548534B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-c08628cd45a0411b858d0782275a6a95 |
| Source note | uspto-grants-2003_04 |