5-Aminophthalide → HCID 18551231, compound

HRID 1266443Notes

Reaction equation

HRID 1266443 reaction equation
Br[C:2]1[C:11]([NH:12][C:13](=[O:26])[C:14](=[O:25])[CH2:15][C:16]([CH3:24])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][O:5][C:6]2=[O:7].NC1C=C2C(=CC=1)C(=O)OC2.[I:38]C1C=CC(C(C)(C)CC(=O)C(O)=O)=CC=1>>[I:38][C:21]1[CH:22]=[CH:23][C:18]([C:16]([CH3:24])([CH3:17])[CH2:15][C:14](=[O:25])[C:13]([NH:12][C:11]2[CH:2]=[C:3]3[C:8](=[CH:9][CH:10]=2)[C:6](=[O:7])[O:5][CH2:4]3)=[O:26])=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 7206695-AminophthalideHCID 18551181HCID 18551181, compoundHCID 185512024-Bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide

Product 1

HCID 18551231HCID 18551231, compound

Procedure

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 5-aminophthalide and 4-(4-iodophenyl)-4-methyl-2-oxo-valeric acid as an oil.

Workup

  1. customwas obtained analogously to the process that

Sources & evidence

ORD record
ord-15e2fba2a20e462288d9392fa9b55d65
Source dataset
uspto-grants-2003_04
Patent number
US06548534B2

Reaction notes

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