HCID 54231958, compound → HCID 56977973, compound

Participants

Reaction Steps

A stirred mixture of 1-acetyl-2-(4-nitro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester (3 g, Reference Example 20) and 10% palladium on charcoal in ethanol (150 mL) was hydrogenated under atmospheric pressure for 4 hours at room temperature and then filtered through a celite pad. The filter pad was washed with ethanol (50 mL) and the combined filtrate plus washings were evaporated. The residue was subjected to flash chromatography on silica (330 g, 20-451 μm, 0.6 bar) eluting with a mixture of dichloromethane and methanol (95:5, v/v). The fractions containing the compound of RF 16/63 (thin layer chromatography plate ref. #05719, Merck KGaA, 64271 Darmstatd, Germany, dichloromethane:methanol, 95:5, v/v) were pooled and evaporated under reduced pressure (2.7 kPa) to give the title compound (1.71 g).

Provenance & Evidence