Hydrochloric Acid → HCID 69953870, compound

Participants

Reaction Steps

Intermediate 1B (320 mg, 1.2 mmol) was treated with 1.31 ml of 1 N NaOH, a small amount of MeOH was added to aid dissolution of the ester. The resulting suspension was stirred for 2 h then acidified with 1N HCl and EtOAc was added. The organic layer was separated, washed with brine, dried over Na2SO4 then filtered and the solvent removed to yield 240 mg oil. The crude product was purified by reverse phase preparative HPLC (C18, MeOH/H2O (0.1% TFA)-gradient). MS (M−H) calcd for C12H10NO4Cl: 253.0268; found: 253.0267.

Provenance & Evidence