4-Fluorobenzaldehyde → E-4-fluorostyryl 4-fluorobenzyl sulfone

HRID 1266486Notes

Reaction equation

HRID 1266486 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[F:16][C:17]1[CH:24]=[CH:23][C:20](C=O)=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7](/[CH:10]=[CH:11]/[C:20]2[CH:23]=[CH:24][C:17]([F:16])=[CH:18][CH:19]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 11447598[(4-Fluorobenzyl)sulfonyl]acetic acid

Product 1

HCID 9948064E-4-fluorostyryl 4-fluorobenzyl sulfoneYield 73%

Procedure

A solution of 4-fluorobenzyl sulfonylacetic acid (0.01 mol) and 4-fluorobenzaldehyde (0.01 mol) was subjected to Procedure 1. The title compound was obtained in 73% yield.

Sources & evidence

ORD record
ord-77d03b622aad4491a0316478170e7d94
Source dataset
uspto-grants-2003_04
Patent number
US06548553B2

Reaction notes

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