HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → Tert-butyl 2-(4-bromophenylthio)-2-methylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Bromothiophenol | HCID 66049 | — |
| Reactant | tert-Butyl 2-bromo-2-methylpropionate | HCID 90290 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl 2-(4-bromophenylthio)-2-methylpropanoate | HCID 10640226 | — |
Reaction Steps
4-Bromothiophenol (100 g) and tert-butyl 2-bromoisobutyrate (118 g) are dissolved in 1 l of ethanol and treated with 29 g of KOH. The mixture is stirred under reflux for 2 h and cooled, and the KBr is filtered off. The filtrate is concentrated and the residue is recrystallized from n-hexane. This gives 93.6 g of a colourless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548538B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-a7adb24bbfcc4883b208b6f9e4bb5764 |
| Source note | uspto-grants-2003_04 |