Sodium Hydroxide → HCID 69894550, compound

HRID 1266536Notes

Reaction equation

HRID 1266536 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:33])[CH2:11][N:12]([CH2:19][C:20]1[CH:32]=[CH:31][C:23]([O:24][C:25]([CH3:30])([CH3:29])[C:26]([OH:28])=[O:27])=[CH:22][CH:21]=1)[CH2:13][C:14]1[O:15][CH:16]=[CH:17][CH:18]=1.[OH-].[Na+:35]>C(O)C>[Na+:35].[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:33])[CH2:11][N:12]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:24][C:25]([CH3:30])([CH3:29])[C:26]([O-:28])=[O:27])=[CH:31][CH:32]=1)[CH2:13][C:14]1[O:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9803821HCID 9803821, compound

Product 1

HCID 69894550HCID 69894550, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.015 g (0.03 mmol) of the compound from Example 3-4 is dissolved in 0.5 ml of ethanol and treated with 0.3 ml of 1N aqueous sodium hydroxide solution. The reaction mixture is stirred for another 5 min and then concentrated using a rotary evaporator. The residue is taken up in a little toluene and the solvent is removed under reduced pressure. The product is then dried under reduced pressure for 20 hours. This gives 0.015 g (95.5% of theory) of the title compound.

Workup

  1. concentrationconcentrated
  2. customa rotary evaporator
  3. customthe solvent is removed under reduced pressure
  4. customThe product is then dried under reduced pressure for 20 hours

Sources & evidence

ORD record
ord-33081a6f005a45a8ab10662ef59735ee
Source dataset
uspto-grants-2003_04
Patent number
US06548538B2

Reaction notes

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