5-Bromovaleric acid → 2,5-Dibromopentanoic acid

HRID 1266539Notes

Reaction equation

HRID 1266539 reaction equation
BrBr.[Br:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].P(Br)(Br)[Br:12]>>[Br:12][CH:7]([CH2:6][CH2:5][CH2:4][Br:3])[C:8]([OH:10])=[O:9]

Participants

4

Reactant 3

HCID 163685-Bromovaleric acidHCID 24408BromineHCID 24614Phosphorus tribromide

Product 1

HCID 129547642,5-Dibromopentanoic acid

Procedure

39 ml of bromine is added to a mixture of 106 g of 5-bromo pentanoic acid and 1 ml of phosphorus tribromide. The reaction mixture is taken to 70˜80° C. for 16 hours 30 minutes. The reaction medium is taken to 100° C. for 15 minutes, then allowed to return to ambient temperature. 147 g of sought product is obtained.

Workup

  1. waitThe reaction medium is taken to 100° C. for 15 minutes
  2. customto return to ambient temperature

Sources & evidence

ORD record
ord-c6fe9688fec24109851edd5c21f0f52e
Source dataset
uspto-grants-2003_04
Patent number
US06548664B1

Reaction notes

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