Tert-Butylamine → 4-(Tert-butylcarbamoyl)-2-methoxybenzenesulphonyl chloride

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Reaction Steps

Reacting the 3-methoxy-4-sulfobenzoic acid mono-potassium salt with an inorganic acid halogenide the 4-chlorosulfonyl-3-methoxybenzoyl chloride is obtained. To our surprise we have found that at lower temperature, in an appropriate solvent the t-butylamine reacts selectively with the aromatic acid chloride. Thus, the desired 2-methoxy-4-(N-t-butylaminocarbonyl)benzenesulfonyl chloride is obtained in 92% yield, with a purity of 96%, so it can be used without further purification for the synthesis of drug substances.

Provenance & Evidence