Sulfuryl chloride → 2-Chloro-1-(2,4-dimethylphenyl)-2-methyl-1-propanone

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Reaction Steps

2,2′,4′-Trimethylpropiophenone (30.0 g, 0.17 mole) was dissolved in heptane (10 ml), and sulfuryl chloride (35 g, 0.26 mole) was added at once. After about 5 min gas evolution occurred. After 3 h of stirring at room temperature the reaction mixture was concentrated. The concentrate was dissolved in heptane (200 ml) and was washed with 150 ml of a 2 wt % aqueous sodium bicarbonate solution. After drying over magnesium sulfate the solvent was removed under reduced pressure. The yield of 2-chloro-2,2′,4′-trimethylpropiophenone was 35.5 g or 99%.

Provenance & Evidence