Hydrochloric Acid → HCID 178466722, compound

Participants

Reaction Conditions

Reaction Steps

The (RS)-[5-ethoxy-2-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-[4-(N-hydroxycarbamimidoyl)-phenylamino]-acetic acid ethyl ester (44 mg) described in example 1.8 was suspended in THF (0.9 ml). A 1 M solution of NaOH (0.101 ml) was added and the mixture was stirred for 30 min at 0° C. and for 2.5 h at room temperature. The mixture was neutralized with 1 M HCl and concentrated to give 42 mg of (RS)-[5-ethoxy-2-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-[4-(N-hydroxycarbamimidoyl)-phenylamino]-acetic acid sodiumchloride as a colorless solid. MS: 408 ([M+H]+).

Provenance & Evidence