참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | (S)-(+)-3-Hydroxytetrahydrofuran | HCID 2733227 | — |
| 반응물 | (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester | HCID 69924374 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 70002924 | HCID 70002924 | — |
반응 단계
To a solution of 7.38 g (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester described in example 3.5 in 220 ml THF were added 1.68 ml (S)-(+)-3-hydroxy-tetrahydrofurane and 6.48 g triphenylphosphine. The mixture was cooled to 0° C. Subsequently, 3.84 ml of diethyl azodicarboxylate were added. The solution was stirred for 3 hrs at room temperature, then evaporated. The crude product was purified by chromatography on silica gel (cyclohexane/EtOAc) to give 6.53 g of (RS)-(4-cyano-phenylamino)-[5-ethoxy-2-fluoro-3-[(R)-tetrahydro-furan-3-yloxy]-phenyl]-acetic acid ethyl ester as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06548694B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_04 |
|---|
| ORD ID | ord-8708f82d8a404e0d8bad03a6f2b4a691 |
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| 출처 메모 | uspto-grants-2003_04 |
|---|
