HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → (4-Cyano-5-morpholin-4-yl-2-nitro-phenyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-(Boc-amino)-2-fluoro-5-nitrobenzonitrile | HCID 69687274 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (4-Cyano-5-morpholin-4-yl-2-nitro-phenyl)-carbamic acid tert-butyl ester | HCID 69780848 | — |
Reaction Steps
The title compound was prepared from (4-cyano-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A10) (4.67 g, 16.6 mmol) and morpholine (7.21 ml, 82.8 mmol) in DMSO (30 mL) at RT according to the general procedure B. Obtained as a yellow solid (5.01 g, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-97c00843e0d245dbb4735e6480e28c60 |
| Source note | uspto-grants-2003_04 |