HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → (4-Cyano-2-nitro-5-thiomorpholin-4-yl-phenyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 4-(Boc-amino)-2-fluoro-5-nitrobenzonitrile | HCID 69687274 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (4-Cyano-2-nitro-5-thiomorpholin-4-yl-phenyl)-carbamic acid tert-butyl ester | HCID 69780718 | — |
Reaction Steps
The title compound was prepared from (4-cyano-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A10) (2.00 g, 7.11 mmol) and thiomorpholine (3.38 ml, 35.6 mmol) in DMSO (30 mL) at RT according to the general procedure C. Obtained as a light yellow solid (2.20 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-5c29e3e9f9e143749dc77446a2219310 |
| Source note | uspto-grants-2003_04 |