Sodium borohydride → [1-(3-Amino-4-nitro-phenyl)-1H-pyrrol-3-yl]-methanol

HRID 1266739Notes

Reaction equation

HRID 1266739 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:15]=[CH:14][C:13]([CH:16]=[O:17])=[CH:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[BH4-].[Na+]>CCO>[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18548903HCID 18548903, compound

Product 1

HCID 18548757[1-(3-Amino-4-nitro-phenyl)-1H-pyrrol-3-yl]-methanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 1-(3-amino-4-nitro-phenyl)-1H-pyrrole-3-carbaldehyde (Example F4) by reduction with 2 eq. NaBH4 in EtOH at 23° C. for 30 min. Obtained as a brown solid (20 mg).

Sources & evidence

ORD record
ord-6d6b01645ae8489bae3b85b4e52549c4
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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