HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-cyanopyridine-4-carboxylate → 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-cyanopyridine-4-carboxylate | HCID 13415157 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Product | 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester | HCID 69592816 | — |
Reaction Steps
The title compound was prepared from 2-cyano-isonicotinic acid ethyl ester [CAS-No. 58481-14-4] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a light brown solid (7.70 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-1b45b8e79e8b47968366c35b0a093ee2 |
| Source note | uspto-grants-2003_04 |