Methyl 3-(1H-pyrazol-1-yl)benzoate → 3-Oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert-butyl ester

HRID 1266765Notes

Reaction equation

HRID 1266765 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH:14]=[CH:13][CH:12]=[N:11]2)[CH:5]=1.[C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[CH3:17].[Li]>>[C:20]([O:19][C:16](=[O:18])[CH2:17][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH:14]=[CH:13][CH:12]=[N:11]2)[CH:5]=1)([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 11171669Methyl 3-(1H-pyrazol-1-yl)benzoateHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696875573-Oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert-butyl ester

Procedure

The title compound was prepared from 3-pyrazol-1-yl-benzoic acid methyl ester [CAS-No. 168618-35-7] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (5.00 g).

Sources & evidence

ORD record
ord-4028fd05c3364c9183fb362d9b0c7e76
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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