Bromine → Rac-3-(2-bromo-propionyl)-benzoic acid methyl ester

HRID 1266769Notes

Reaction equation

HRID 1266769 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12][CH3:13])=[O:11])(=[O:6])[CH2:4][CH3:5]>C(OCC)C>[Br:1][CH:4]([CH3:5])[C:3]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12][CH3:13])=[O:11])=[O:6]

Participants

4

Reactant 2

HCID 24408BromineHCID 22139792Methyl 3-propionylbenzoate

Product 1

HCID 22139798Rac-3-(2-bromo-propionyl)-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (4.6 ml) was dropped at 20-30° C. over 20 min. to a solution of methyl 3-propionyl-benzoate (17.24 g) in diethyl ether (0.15 L). Stirring was continued for 10 min. and the reaction mixture was then evaporated in vacuum to give methyl 3-(2-bromo-propionyl)-benzoate (25.5 g) as a yellow oil.

Workup

  1. customthe reaction mixture was then evaporated in vacuum

Sources & evidence

ORD record
ord-74be0b2a9a71406982fbb3544a6f1b70
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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