Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1266785Generated: November 3, 2026

3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-pyrrol-1-yl-phenyl}-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/1266785

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 11736337—
Reactant(2-Amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl esterHCID 69488996—
Product{2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-pyrrol-1-yl-phenyl}-carbamic acid tert-butyl esterHCID 86586968—

Reaction Steps

The title compound was prepared from (2-amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert.-butyl ester (Example J2) (137 mg, 0.5 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) (115 mg, 0.5 mmol) according to the general procedure M. Obtained as a light red solid (139 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06548495B2
Source datasetuspto-grants-2003_04
ORD IDord-b6922ed8e7c24a5aae2ecbce83bc7421
Source noteuspto-grants-2003_04