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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1266787Generated: October 31, 2026

3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → 3-(3-Cyano-phenyl)-N-[5-(3-cyano-4-phenyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide

https://huagongshe.com/reaction/1266787

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 11736337—
Reactant1-(3-Amino-4-nitro-phenyl)-4-phenyl-1H-pyrrole-3-carbonitrileHCID 18548863—
Product3-(3-Cyano-phenyl)-N-[5-(3-cyano-4-phenyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamideHCID 18548780—

Reaction Steps

The title compound was prepared from 1-(3-amino-4-nitro-phenyl)-4-phenyl-1H-pyrrole-3-carbonitrile (Example E3) (254 mg, 0.835 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) (210 mg, 0.919 mmol) according to the general procedure M. Obtained as an orange solid (287 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06548495B2
Source datasetuspto-grants-2003_04
ORD IDord-389b17cb314f47a1887701e8723da7b2
Source noteuspto-grants-2003_04