HCID 12048026, compound → {5-Morpholin-4-yl-2-[3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester

HRID 1266808Notes

Reaction equation

HRID 1266808 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH2:24])([CH3:4])([CH3:3])[CH3:2].C([O:30][C:31](=O)[CH2:32][C:33](=[O:45])[C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([N:40]2[CH:44]=[CH:43][CH:42]=[N:41]2)[CH:35]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:11]([C:20]([F:21])([F:22])[F:23])=[CH:10][C:9]=1[NH:24][C:31](=[O:30])[CH2:32][C:33](=[O:45])[C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([N:40]2[CH:44]=[CH:43][CH:42]=[N:41]2)[CH:35]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 12048026HCID 12048026, compoundHCID 696875573-Oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert-butyl ester

Product 1

HCID 86586984{5-Morpholin-4-yl-2-[3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (2-amino-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example J1) (361 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazol-1-yl-phenyl)-propionic acid tert.-butyl ester (Example K12) (286 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (367 mg).

Workup

  1. customObtained as a light yellow amorphous substance (367 mg)

Sources & evidence

ORD record
ord-aa95cc6747ce4579b86c28892caf9d6e
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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