HCID 18548744, compound → {5-Methoxy-2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester

HRID 1266813Notes

Reaction equation

HRID 1266813 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:28][C:27](=O)[CH:26]=[C:25]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([N:36]3[CH:40]=[CH:39][N:38]=[N:37]3)[CH:31]=2)[O:24]1>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=1[NH:20][C:27](=[O:28])[CH2:26][C:25](=[O:24])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([N:36]2[CH:40]=[CH:39][N:38]=[N:37]2)[CH:31]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 18548744HCID 18548744, compoundHCID 69489607Carbamic acid,n-[2-amino-5-methoxy-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

Product 1

HCID 86586990{5-Methoxy-2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (2-amino-5-methoxy-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example J9) (306 mg. 1.0 mmol) and 2,2-dimethyl-6-(3-[1,2,3]triazol-1-yl-phenyl)-[1,3]dioxin-4-one (Example L9) (271 mg, 1.0 mmol) according to the general procedure M. Obtained as a yellow solid (394 mg).

Sources & evidence

ORD record
ord-452d73d0fd674d04a7a4ca0d491c493c
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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