HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Cyano-phenyl)-N-[5-(3-cyano-4-phenyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide → 1-[2-(3-Cyano-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-4-phenyl-1H-pyrrole-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Cyano-phenyl)-N-[5-(3-cyano-4-phenyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide | HCID 18548780 | — |
| Catalyst | Eisenazetat | HCID 45051903 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 1-[2-(3-Cyano-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-4-phenyl-1H-pyrrole-3-carbonitrile | HCID 18548867 | — |
Reaction Steps
The title compound was prepared from 3-(3-cyano-phenyl)-N-[5-(3-cyano-4-phenyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide (Example M7) by reductive cyclization with Fe/HOAc in THF/H2O at 80° C. according to the general procedure J (method d). Obtained as a brown solid (206 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-3a971af3a05e4329b1256bba234d28be |
| Source note | uspto-grants-2003_04 |