HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-(3-Iodo-phenyl)-8-pyrrol-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | HCID 18548906 | HCID 18548906 | — |
| Product | 4-(3-Iodo-phenyl)-8-pyrrol-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18548720 | — |
Reaction Steps
The title compound was prepared from 3-(3-iodo-phenyl)-N-(2-nitro-4-pyrrol-1-yl-phenyl)-3-oxo-propionamide (Example M8) by reductive cyclization with SnCl2.2H2O in EtOH at 70° C. according to the general procedure J (method b). Obtained as an olive solid (624 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-21740e4ff4df4f7bac0b2748849982b9 |
| Source note | uspto-grants-2003_04 |