HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → 3-(8-Iodo-4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 3-(3-Cyano-phenyl)-N-(4-iodo-2-nitro-5-pyrrol-1-yl-phenyl)-3-oxo-propionamide | HCID 18548809 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(8-Iodo-4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile | HCID 18548791 | — |
Reaction Steps
The title compound was prepared from 3-(3-cyano-phenyl)-N-(4-iodo-2-nitro-5-pyrrol-1-yl-phenyl)-3-oxo-propionamide (Example M9) by reductive cyclization with SnCl2.2H2O in EtOH at 70° C. according to the general procedure J (method b). Obtained as a yellow solid (344 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-c48f3a4678a44d9eab96be993c3d98b2 |
| Source note | uspto-grants-2003_04 |