HCID 69780447, compound → HCID 86587005, compound

HRID 1266848Notes

Reaction equation

HRID 1266848 reaction equation
C(O[C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5])C>NCCO>[OH:5][CH2:4][CH2:6][NH:7][C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5]

Participants

3

Reactant 1

HCID 69780447HCID 69780447, compound

Product 1

HCID 86587005HCID 86587005, compoundYield 110.5%

Reagents, catalysts & solvents 1

HCID 700EthanolamineSolvent

Procedure

A solution of 5-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid ethyl ester (Example 23) (35mg) in 2-amino-ethanol (1 mL) was stirred at 50° C. for 4 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (20 mg) as light-yellow solid.

Workup

  1. customThe mixture was partitioned between H2O and EtOAc
  2. customThe organic layer was dried
  3. customevaporated in vacuum
  4. customthe residue was triturated with EtOAc

Sources & evidence

ORD record
ord-4d3393e9a666440b84cd00455139561c
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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