HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[3-(2-Methyl-2H-pyrazol-3-yl)-phenyl]-7-morpholin-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-{3-[3-(2-Methyl-2H-pyrazol-3-yl)-phenyl]-3-oxo-propionylamino}-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester | HCID 86586976 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[3-(2-Methyl-2H-pyrazol-3-yl)-phenyl]-7-morpholin-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18548756 | — |
Reaction Steps
The title compound was prepared from (2-{3-[3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-3-oxo-propionylamino}-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example M22) (100 mg, 0.17 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (32 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548495B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-404f079a7a664f639e56b46f7fe2e6f6 |
| Source note | uspto-grants-2003_04 |