反应详情

A solution of 5-iodouracil (commercially available from Aldrich, 2 g, 8.4 mmol) in dry pyridine (20 mL) was added dropwise to a solution of benzoyl chloride (3.5 g, 25.3 mmol) in pyridine (10 mL). The mixture was stirred at room temperature for 3 hours. Water (70 mL) was added and the product extracted with ethyl acetate. The organic phase was washed with a saturated solution of NH4Cl and then with 2% HClaq (40 mL×4 times) The solvent was removed under vacuum and the residue was triturated with i-Pr2O to give the title compound as white solid (2.6 g, 90% yield).

1. extractionthe product extracted with ethyl acetate
2. washThe organic phase was washed with a saturated solution of NH4Cl
3. customwith 2% HClaq (40 mL×4 times) The solvent was removed under vacuum
4. customthe residue was triturated with i-Pr2O