Hydrochloric Acid → HCID 178457597, compound

Participants

Reaction Steps

A mixture of 656 g (2.00 mole) of 1-[3(4-Chlorophenoxy)propyloxy-5-isopropylbiguanide and 1.0 L of EtOAc was swirled and cooled in an ice bath before 500 g of EtOAc containing 74.5 (2.04 moles) of HCl was added. After 10 minutes a second 500 g (2.04 moles) of the HCl in EtOAc was added in small portions with swirling and cooling in the ice bath. The thick precipitate was thinned with 500 mL of EtOAc. After air-drying the material was ground with a mortar and pestle, dried at 50° C., and then at a vacuum of 1 mm to give 793 g (99%) of product mp 160-165° C.

Provenance & Evidence