Dimethylformamide → HCID 14676216, compound

Participants

Reaction Conditions

Reaction Steps

A reaction flask was loaded with 2-amino-3-hydroxypyridine (8 g), dimethylformamide (DMF) (50 ml), and anhydrous potassium carbonate (12 g), and the temperature was raised up to 50° C. with stirring, followed by dropwise addition of n-butylbromide (11.9 g) to the flask in 4 hours with stirring. Then, the mixture was stirred at 60° C. for 2 hours. The heating was stopped, and water (200 ml) was added to the mixture. Ethyl acetate was added to the mixture and the mixture was stirred, followed by collecting the ethyl acetate layer with a separating funnel. The layer was condensed by an evaporator to precipitate crystals, and then the crystals were broken up with hexane. The crystals were filtrated for collection and dried to give crystals of 2-amino-3-butoxypyridine (5 g).

Provenance & Evidence