反应详情

温度

110 °C

Then, a flask was loaded with acetic acid (50 ml) and 1,2-naphthoquinone (2.9 g), and the temperature was raised up to 110° C. with stirring to dissolve 1,2-naphthoquinone. To this mixture, 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine (4 g) was added in 30 minutes. After stirring at 110° C. for 3 hours, the heating was stopped and left to cool. The reaction mixture was filtrated. The filtrated crystals were recrystallized with dioxane to give crystals, which were then filtrated and dried to give intended crystals (2.3 g).

1. stirringAfter stirring at 110° C. for 3 hours
2. waitleft
3. temperatureto cool
4. filtrationThe reaction mixture was filtrated
5. customThe filtrated crystals were recrystallized with dioxane
6. customto give crystals, which
7. filtrationwere then filtrated
8. customdried
9. customto give