HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Methoxy-2-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Hydroxy-2-nitropyridine | HCID 27057 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Methoxy-2-nitropyridine | HCID 556063 | — |
Reaction Steps
A reaction flask was loaded with 3-hydroxy-2-nitropyridine (20 g), dimethylformamide (80 ml), and potassium carbonate (23.4 g), and they were mixed, followed by dropwise addition of methyl iodide (52.4 g) to the flask in 2.2 hours. After stirring overnight, water was added to this for crystallization. The crystals were filtrated for collection and dried to give 3-methoxy-2-nitropyridine (16.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06551682B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-cef182f31f4c4f95bfaa7796b4f29b2f |
| Source note | uspto-grants-2003_04 |