Isoamyl Nitrite → HCID 135718525, compound

Participants

Reaction Steps

Next, a flask was loaded with sodium ethylate (1.6 g), ethanol (14 ml), and 2-amino-3-propoxypyridine (3.8 g), and they were mixed. To the mixture, isopentyl nitrite (2.7 g) was dropwise added in 20 minutes with stirring. This was stirred at the reflux temperature for 4 hours, and then cooled to room temperature. Thereafter, to this, 2-naphthol (2.0 g) dissolved in ethanol (5 ml) was dropwise added in one hour. After stirring at room temperature for two hours, this mixture was heated to the reflux temperature, followed by stirring for additional 2 hours. The reaction mixture was filtrated and the filtrate was condensed to precipitate crystals. The crystals were filtrated for collection and recrystallized with dioxane-water to give intended crystals (0.59 g).

Provenance & Evidence