Benzyl Bromide → HCID 12549418, compound

Participants

Reaction Conditions

Reaction Steps

A solution of lepidine (37.82 g) and benzyl bromide (6.471 g) in acetonitrile (100 mL) were stirred and heated to reflux in an oil bath at 93° C. for 20 hours. Cooled the reaction mixture to room temperature, added ethyl acetate (50 mL) and stirred for 30 min. The resultant solid was collected, washed with ethyl acetate (4×20 mL) and dried in the air. The filtrate was concentrated to a small volume and a second crop of solid was also collected. The combined solid was dried in an oven under high vacuum at 50° C. overnight. There was obtained 11.52 g (96.9%) of product.

Provenance & Evidence