Glutaric anhydride → HCID 86585499, compound

Participants

Reaction Steps

Paclitaxel (0.43 g, 0.5 mmol) and glutaric anhydride (0.68 g, 6 mmol) were dissolved in 5 ml of pyridine and stirred at room temperature for 3 hours. In the end of reaction, the solution was evaporated to dryness in vacuo. The residues were treated with 20 ml water with stirring for 20 min and filtered. The precipitates were redissolved in acetone and water was added to produce fine crystals of paclitaxel-glutarate (0.42 g, 86% yields). The analytic result gave [M+H]+=968 Da by ESMs. The paclitaxel-glutarate complex has the following structure:

Provenance & Evidence