HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → 1-(3,4-Dimethylphenyl)-3-methyl-3-pyrazolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 1-(3,4-Dimethylphenyl)hydrazine | HCID 173741 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(3,4-Dimethylphenyl)-3-methyl-3-pyrazolin-5-one | HCID 11735829 | 156.7% |
Reaction Steps
A solution of 3,4-dimethylphenylhydrazine (7.3 g; 0.053 mol.) and ethyl acetoacetate (6.9 g; 0.053 mol.) in glacial acetic acid (50.0 mL) was stirred and heated at 100° for 24h. The solvent was evaporated and the product purified by chromatography (silica gel, 50% ethyl acetate/hexanes) to afford the title compound (16.8 g; 64%). MS(ES) m/z 203 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552008B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-b21cc4eb0d6c4b44896137eafef76b5c |
| Source note | uspto-grants-2003_04 |