4-Methyloxybenzyl chloride → 2-{4-[4-(2,6-difluorophenyl)-2-hydroxybutyl]piperazinyl}-N-(2,6-dimethylphenyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	4-Methyloxybenzyl chloride	HCID 69993	—
Reactant	2,6-Difluorobenzyl chloride	HCID 581570	—
Reactant	N-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamide	HCID 12052937	—
Product	2-{4-[4-(2,6-difluorophenyl)-2-hydroxybutyl]piperazinyl}-N-(2,6-dimethylphenyl)acetamide	HCID 10113598	—

Reaction Steps

Compound 17 was prepared in a manner similar to that of compound 16 substituting 2,6-difluorobenzyl chloride for 4-methoxybenzyl chloride. (M+1)=432.2

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06552023B2
Source dataset	uspto-grants-2003_04
ORD ID	ord-e7bfede09a574071aa91e61b5ed4097e
Source note	uspto-grants-2003_04