Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1267026Generated: October 27, 2026

4-Methyloxybenzyl chloride → 2-(4-{4-[4-(tert-butyl)phenyl]-2-hydroxybutyl}piperazinyl)-N-(2,6-dimethylphenyl)acetamide

https://huagongshe.com/reaction/1267026

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methyloxybenzyl chlorideHCID 69993—
ReactantBenzene, 1-(chloromethyl)-4-(1,1-dimethylethyl)-HCID 88198—
ReactantN-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamideHCID 12052937—
Product2-(4-{4-[4-(tert-butyl)phenyl]-2-hydroxybutyl}piperazinyl)-N-(2,6-dimethylphenyl)acetamideHCID 10275771—

Reaction Steps

Compound 19 was prepared in a manner similar to that of compound 16 substituting 4-t-butylbenzyl chloride for 4-methoxybenzyl chloride. (M+1)=452.3

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06552023B2
Source datasetuspto-grants-2003_04
ORD IDord-71a8a2db4ef5491090d6bf84119e2d12
Source noteuspto-grants-2003_04