HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyloxybenzyl chloride → N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-4-[4-(trifluoromethyl)phenyl]butyl}piperazinyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | p-Trifluoromethylbenzyl chloride | HCID 123096 | — |
| Reactant | N-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamide | HCID 12052937 | — |
| Product | N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-4-[4-(trifluoromethyl)phenyl]butyl}piperazinyl)acetamide | HCID 10276533 | — |
Reaction Steps
Compound 21 was prepared in a manner similar to that of compound 16 substituting 4-trifluoromethylbenzyl chloride for 4-methoxybenzyl chloride. (M+1)=464.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552023B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-eee3d3073cd4467aa6155cd9d0138417 |
| Source note | uspto-grants-2003_04 |