Triethylamine → HCID 60209506, compound

Participants

Reaction Steps

To a solution of (2S,4R)-4-(3,4-dichlorobenzyl)-1-tert-butoxycarbonyl-2-(hydroxymethyl)pyrrolidine (1.38 g, 3.82 mmol) in methylene chloride (30 mL) was added triethylamine (0.78 mL, 5.72 mmol) followed by methanesulfonyl chloride (0.36 mL, 4.58 mmol) and the mixture was stirred at 20° for 9 hrs. Most CH2Cl2 was then removed by evaporation in vacuo, and the residue was diluted with ethyl acetate and washed with aqueous NaHCO3 followed by water. Drying with Na2SO4 followed by evaporation in vacuo gave 1.70 g of crude (2S,4R)-4-(3,4-dichlorobenzyl)-1-tert-butoxycarbonyl-2-(methanesulfonyloxymethyl)pyrrolidine, which was used without further purification.

Provenance & Evidence