Ethyl Acetate → HCID 20579057, compound

Participants

Reaction Steps

To a CH2Cl2 solution of (2R,4R)-2-aminomethyl-4-(3,4-dichlorobenzyl)-1-methyl-pyrrolidine (prepared as described in example 4.4) (40 mg, 0.15 mmol) was added 5-phenylpyrimidin-2-ylthioacetic acid (40 mg, 0.16 mmol), EDCI (36 mg, 0.19 mmol), and HOBT (2 mg, 0.015 mmol) The reaction mixture was stirred for 16 h at room temperature and then diluted with EtOAc and washed with aqueous NaHCO3. The organic layer was dried over MgSO4, filtered, and concentrated. Flash chromatography (95% CH2Cl2/5% MeOH) provided N-(2R,4R)-[4-(3,4-dichlorobenzyl)-1-methylpyrrolidin-2-ylmethyl]-2-[5-(phenyl)pyrimidin-2-ylsulfanyl]acetamide hydrochloride (47 mg, 0.098 mmol) mass spectrum 502 (MH+).

Provenance & Evidence