HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → tert-Butyl [4-(piperazin-1-yl)phenyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Carbamic acid, [4-[4-(phenylmethyl)-1-piperazinyl]phenyl]-, 1,1-dimethylethyl ester | HCID 54469150 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl [4-(piperazin-1-yl)phenyl]carbamate | HCID 16244582 | 53.3% |
Reaction Steps
A solution of [4-(4-benzyl-piperazine-1-yl)-phenyl)-carbamic acid tert-butyl ester (43.5 g) in EtOH (1 L) containing Pd/C 10% (4 g) was hydrogenated at room temperature. After 72 hours, the catalyst was removed by filtration and the filtrate was evaporated under reduced pressure. The oily residue was then purified by flash chromatography eluting with AcOEt/isopropylamine (90/10) and the solid obtained was recristallized from AcOEt to give the title compound (17.5 g) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552022B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-e3e906b355324618b7b5f0b8b358330b |
| Source note | uspto-grants-2003_04 |