Potassium Carbonate → HCID 53713961, compound

Participants

Reaction Steps

To a solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid (3-piperazin-1-yl-phenyl)-amide (0.5 g) in acetone (20 mL) containing K2CO3 (0.19 g) was added 3-cyano-benzyl bromide (0.23 g) and the mixture was heated at reflux for 2 hours. The solution was cooled at room temperature and the salts were removed by filtration, washed with acetone and the filtrate was evaporated under reduced pressure. The residue was purified by crystallizatiori from AcOEt to give the title compound (0.17 g) as white crystals.

Provenance & Evidence