Hydrochloric Acid → HCID 18545516, compound

Participants

Reaction Steps

To a solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid [4-[4-(3-carbomethoxy-benzyl)-piperazin-1-yl]-phenyl]-amide (1.6 g) in EtOH (100 mL) was added 1N sodium hydroxide (5.6 mL) and the mixture was stirred under reflux for 16 hours. The solution was cooled at room temperature and acidified with 1N hydrochloric acid (5.6 mL). The white precipitate obtained was filtered and recristallized from EtOH to give the title compound (1.4 g) as white crystals. m.p.: 225-227° C.

Provenance & Evidence