反应详情

A solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide (212 mg) in acetic anhydride (10 mL) was stirred at room temperature for 16 hours. The solution was evaporated under reduced pressure, and the residue was dissolved in CH2Cl2 and washed with a saturated solution of NaHCO3, with brine, dried over Na2SO4, filtered and evaporated. The oily residue was crystallized from AcOEt to give the title compound (130 mg) as white crystals.

1. customThe solution was evaporated under reduced pressure
2. dissolutionthe residue was dissolved in CH2Cl2
3. washwashed with a saturated solution of NaHCO3, with brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated
7. customThe oily residue was crystallized from AcOEt