Citric Acid → 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-[4-(3-cyano-benzyl)-piperazin-1-yl]-phenyl]-amide citrate salt

HRID 1267139ノート

反応式

HRID 1267139 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:38]=[CH:39][CH:40]=1)[CH2:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20]([C:22]3[C:23]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=4)=[CH:24][CH:25]=[CH:26][CH:27]=3)=[O:21])=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)#[N:2].[C:41]([OH:53])(=[O:52])[CH2:42][C:43]([CH2:48][C:49]([OH:51])=[O:50])([C:45]([OH:47])=[O:46])[OH:44]>CO>[C:41]([OH:53])(=[O:52])[CH2:42][C:43]([CH2:48][C:49]([OH:51])=[O:50])([C:45]([OH:47])=[O:46])[OH:44].[C:1]([C:3]1[CH:4]=[C:5]([CH:38]=[CH:39][CH:40]=1)[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:20]([C:22]3[C:23]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:36])([F:37])[F:35])=[CH:30][CH:29]=4)=[CH:24][CH:25]=[CH:26][CH:27]=3)=[O:21])=[CH:17][CH:18]=2)[CH2:11][CH2:12]1)#[N:2]

参加物

4

反応物 2

HCID 311Citric AcidHCID 98073154'-Trifluoromehtyl-biphenyl-2-carboxylic acid [4-[4-(3-cyano-benzyl)-piperazin-1-yl]-phenyl]-amide

生成物 1

HCID 865913074'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-[4-(3-cyano-benzyl)-piperazin-1-yl]-phenyl]-amide citrate salt収率 55.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid [4-[4-(3-cyano-benzyl)-piperazin-1-yl]-phenyl]-amide (0.2 g) in MeOH (15 mL) was added citric acid (71 mg) and the resulting solution was stirred at room temperature. The solution was then evaporated to dryness and the solid was triturated in Et2O, filtered and dried to give the title compound (0.15 g) as a white powder.

後処理

  1. customThe solution was then evaporated to dryness
  2. customthe solid was triturated in Et2O
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-12bee99cee404722b5daf00838a8d544
出典データセット
uspto-grants-2003_04
特許番号
US06552022B1

反応ノート

読み込み中…