HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-3-nitrobenzonitrile → 3-Amino-4-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-3-nitrobenzonitrile | HCID 76758 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-4-hydroxybenzonitrile | HCID 271258 | 100.2% |
Reaction Steps
A solution of 4-hydroxy-3-nitrobenzonitrile (10 g, 61 mmol) in MeOH (200 mL) was treated with hydrogen gas through a balloon in the presence of 5% Pd on active carbon (0.5 g) at room temperature for 24 hours. The mixture was filtered, and the filtrate was concentrated to give the product (8.2 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552042B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-ca038a9f7957461f86e2cc7fb1aedf84 |
| Source note | uspto-grants-2003_04 |