Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → 4-(6-Acetylaminoindan-1-yl)butanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Indane | HCID 10326 | — |
| 반응물 | 6-Nitro-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 12318488 | — |
| 생성물 | 4-(6-Acetylaminoindan-1-yl)butanoic acid | HCID 18545843 | — |
| 생성물 | 2-(6-Acetylaminoindan-1-yl)acetic acid | HCID 18545899 | — |
| 생성물 | 3-(6-Acetylaminoindan-1-yl)propanoic acid | HCID 18545930 | — |
반응 단계
2-(6-acetylaminoindan-1-yl)acetic acid, 3-(6-acetylaminoindan-1-yl)propanoic acid and 4-(6-acetylaminoindan-1-yl)butanoic acid were prepared from 6-nitro-1-indanecarboxylic acid by classical chain elongations by using KCN or diethyl malonate. The methodology is described for an analogous indane serie by R. Gruber et al. Tetrahedron 1974, 30, 3605-10. Alane was used for the reduction of the intermediate carboxylic acids.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06552044B2 |
| 출처 데이터셋 | uspto-grants-2003_04 |
| ORD ID | ord-edf5d2dd411a45418a1a807bd77dd981 |
| 출처 메모 | uspto-grants-2003_04 |