HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl iodide → 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl iodide | HCID 10556 | — |
| Reactant | 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione | HCID 283534 | — |
| Product | 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 22312768 | — |
Reaction Steps
2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 4-M using the product from Example 4-P, Step A and 1-iodo-2-methylpropane (Aldrich). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to 1:1), then recrystalization from EtOAc/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552013B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-3a14b31a853c4aaf852a294f189670cd |
| Source note | uspto-grants-2003_04 |